Feb 16 2009 10:03 PM I'd just like to add that the curse that Misuzu suffered, which originated from Kanna whom who see in the second arc, is that she gets sick as she gets close to people. So it's not really that Yukito leaving gave her life force or something like that, but it's simply that since he wasn't close to her then she wasn't as sick.
Now, in the last arc, Misuzu starts to get closer and closer to her aunt Haruko. As the two grow closer Misuzu gets sicker and sicker. Soon she is resigned to a wheelchair because she doesn't have strength enough to move. However, Misuzu was determined that she would have a friend, and that she wouldn't let her curse get in the way of her goal, that of being close to her aunt, even if it killed her. So, symbolically, in the last scene we see Misuzu straining to walk, on her own, to reach her 'goal', the arms of her now-loving aunt. She struggles but eventually makes it there, thus breaking the curse so none of the others who inherit the curse need to suffer, but also ending her life.
Another thing I'd like to add is that I don't think Yukito being there was the reason that Kano went suicidal or Michiru appeared or Misuzu's dreams started, because I believe Misuzu has said that she had those dreams before Yukito came, just that she was having them more often now (most likely because they were becoming closer). Kano had already flipped out when she was young (which is why she had that ribbon), and Michiru was bouncing around before Yukito ever showed up.
Though I can't wait to see this series again
